San Luis have officially handed the head coach role to Diego Milito.
Cruz Azul, meanwhile, have kept Joel Viki on permanently after he led the team to the championship as caretaker boss at the end of last season.
San Luis have no suspensions. Cesar Lopez is doubtful with a knee injury, while there are no other reported absences.
Cruz Azul have no suspensions, no doubtful players, and no reported injuries or absentees.
San Luis finished 14th in the Clausura and missed out on the playoffs. They have shown flashes in attack, but their performances have been inconsistent over the long run and their defensive discipline has been lacking. New boss Diego Milito is expected to bring more structure to an unstable side, but his first league match is a stern test against the defending champions.
Cruz Azul signed off last season in perfect fashion by beating Pumas 2-1 in the second leg of the final to win the title. Joel Viki was appointed in difficult circumstances late in the campaign, but he guided the side through an excellent playoff run, so his permanent appointment was fully deserved. The challenge this season is handling the pressure of defending the crown, but Cruz Azul have a strong foundation and plenty of belief.
San Luis may have home advantage, but with a new coach and a new system, they are hard to trust in the opening round. Cruz Azul look the steadier side, arrive with the momentum of champions, and are backed to take all three points away from home.
In the last seven meetings between the two teams, Cruz Azul have won six and lost one. Their most recent league meeting came in March last year, when Cruz Azul cruised to a 3-0 home win.